What causes high iron saturation?

By Melanie Bieli, On 23rd May 2021, Under Business and Services
Ferritin blood test measures the level of ferritin.
High levels of ferritin can be indicative of an iron storage disorder such as hemochromatosis. Other causes of a high ferritin level are chronic inflammatory conditions such as liver disease or rheumatoid arthritis, or some types of cancer.

Thereof, what does it mean to have high iron saturation?

The serum transferrin saturation test measures the amount of iron bound to transferrin — a protein that carries iron in the blood. Saturation values of more than 45% are too high. The serum ferritin test measures the amount of iron that the body has stored.

Furthermore, what does high TSAT mean?

1 A TSAT level of >50% is more suggestive of iron overload, as it increases the likelihood of direct transfer of iron to parenchymal tissues. TSAT levels of >50%, however, are less common than elevated serum ferritin levels.

How is high iron saturation treated?

Treatment
  1. Phlebotomy. Phlebotomy, or venesection, is a regular treatment to remove iron-rich blood from the body.
  2. Chelation. Iron chelation therapy involves taking oral or injected medicine to remove excess iron from the body.
  3. Dietary changes. Dietary changes to limit iron intake can help reduce symptoms.

How do you lower iron saturation?

Lifestyle and home remedies
  1. Avoid iron supplements and multivitamins containing iron. These can increase your iron levels even more.
  2. Avoid vitamin C supplements. Vitamin C increases absorption of iron.
  3. Avoid alcohol.
  4. Avoid eating raw fish and shellfish.
Symptoms, signs and diseases resulting from too much iron (iron overload):
  • chronic fatigue.
  • joint pain.
  • abdominal pain.
  • liver disease (cirrhosis, liver cancer)
  • diabetes mellitus.
  • irregular heart rhythm.
  • heart attack or heart failure.
  • skin color changes (bronze, ashen-gray green)
Reducing your intake of iron-rich foods, such as red meat. Donating blood regularly. Avoiding taking vitamin C with foods that are rich in iron. Avoid using iron cookware.
If a ferritin test shows higher than normal levels, it could indicate that you have a condition that causes your body to store too much iron. It could also point to liver disease, rheumatoid arthritis, other inflammatory conditions or hyperthyroidism.
Foods to avoid when you have hemochromatosis
  • Excess red meat. Red meat can be a healthy part of a well-rounded diet if eaten in moderation.
  • Raw seafood.
  • Foods rich in vitamins A and C.
  • Fortified foods.
  • Excess alcohol.
  • Supplements.
Normal serum iron test results
Serum iron is measured in micrograms of iron per deciliter of blood (mcg/dL). The following are considered normal ranges for a serum iron test: iron: 60 to 170 mcg/dL. transferrin saturation: 25 percent to 35 percent.
Iron overload (hemochromatosis) can be caused by disorders such as thalassemia (an inherited blood disorder), anemia, chronic alcoholism, and other conditions. In many cases, however, iron overload is the result of a hereditary disorder, which means it is passed down from parents to children through their genes.
Iron deficiency anemia is a frequent complication of advanced liver disease. Several new parameters, such as red blood cell ferritin, serum transferrin receptor test and index, and hepcidin, have been studied for their utility in indicating true iron deficiency in combination with chronic liver disease.
Treatment
  1. Phlebotomy. Phlebotomy, or venesection, is a regular treatment to remove iron-rich blood from the body.
  2. Chelation. Iron chelation therapy involves taking oral or injected medicine to remove excess iron from the body.
  3. Dietary changes. Dietary changes to limit iron intake can help reduce symptoms.
Transferrin saturation (TS), measured as a percentage, is a medical laboratory value. It is the value of serum iron divided by the total iron-binding capacity of the available transferrin, the main protein that binds iron in the blood, this value tells a clinician how much serum iron is bound.
Hereditary hemochromatosis (he-moe-kroe-muh-TOE-sis) causes your body to absorb too much iron from the food you eat. Excess iron is stored in your organs, especially your liver, heart and pancreas. Too much iron can lead to life-threatening conditions, such as liver disease, heart problems and diabetes.
The terms transferrin saturation and iron-binding capacity, saturation, are interchangeable; however, this value is now most commonly referred to simply as transferrin saturation. This minimizes confusion with another value, iron-binding capacity, which is used when determining a patient's iron status.
Normal levels are generally between 35.5 and 44.9 percent for adult women and 38.3 to 48.6 percent for adult men. These values may change depending on your age.
Transferrin saturation ( TSAT ) measures how much of your stored iron can be used to make new red blood cells. Some anemia drugs work by telling your body to make more red blood cells. These drugs are called erythropoiesis stimulating agents, or ESAs .
Ferritin isn't the same thing as iron in your body. Instead, ferritin is a protein that stores iron, releasing it when your body needs it. Transferrin is a protein that combines with ferritin to transport it to where new red blood cells are made.
Premature heart attack, diabetes, liver disease, osteoarthritis, osteoporosis and hormonal imbalances are associated with excess iron. Read more about hemochromatosis in the types of iron disorders. Summary of diseases and conditions that can produce too much iron in adult women include: Loss of menstruation.